Biomarkers in melanoma
Identifieur interne : 001F32 ( Main/Exploration ); précédent : 001F31; suivant : 001F33Biomarkers in melanoma
Auteurs : H. Gogas [Grèce] ; A. M. M. Eggermont [Pays-Bas] ; A. Hauschild [Allemagne] ; P. Hersey [Australie] ; P. Mohr [Allemagne] ; D. Schadendorf [Allemagne] ; A. Spatz [Canada] ; R. Dummer [Suisse]Source :
- Annals of Oncology [ 0923-7534 ] ; 2009.
Abstract
Biomarkers are tumour- or host-related factors that correlate with tumour biological behaviour and patient prognosis. High-throughput analytical techniquesDNA and RNA microarrayshave identified numerous possible biomarkers, but their relevance to melanoma progression, clinical outcome and the selection of optimal treatment strategies still needs to be established. The review discusses a possible molecular basis for predictive tissue biomarkers such as melanoma thickness, ulceration and mitotic activity, and provides a list of promising new biomarkers identified from tissue microarrays that needs confirmation by independent, prospectively collected clinical data sets. In addition, common predictive serum biomarkerslactate dehydrogenase, S100B and melanoma-inhibiting activityas well as selected investigational serum biomarkers such as TA90IC and YKL-40 are also reviewed. A more accurate, therapeutically predictive classification of human melanomas and selection of patient populations that would profit from therapeutic interventions are among the major challenges expected to be addressed in the future.
Url:
DOI: 10.1093/annonc/mdp251
Affiliations:
- Allemagne, Australie, Canada, Grèce, Pays-Bas, Suisse
- Hollande-Méridionale, Québec, Schleswig-Holstein
- Kiel, Montréal, Rotterdam
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Mohr</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, Elbe-Klinikum Buxtehude, Buxtehude</wicri:regionArea><wicri:noRegion>Buxtehude</wicri:noRegion><wicri:noRegion>Buxtehude</wicri:noRegion></affiliation></author><author><name sortKey="Schadendorf, D" sort="Schadendorf, D" uniqKey="Schadendorf D" first="D." last="Schadendorf">D. Schadendorf</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Spatz, A" sort="Spatz, A" uniqKey="Spatz A" first="A." last="Spatz">A. Spatz</name><affiliation wicri:level="3"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, Sir Mortimer B. 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Dummer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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